Invasive Fungal Infections in Patients with Acute Leukemia and Hematopoietic Stem Cell Transplant Recipients
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منابع مشابه
Underestimating the real burden of invasive fungal infections in hematopoietic stem cell transplant recipients?
Fungal infections have historically been, and remain important causes of transplant-related morbidity in recipients of hematopoietic stem cell transplant (HSCT). However, there have been notable changes in the epidemiology and outcomes of invasive fungal infections, induced by changes in the transplant procedures as well as supportive care. This review discusses invasive fungal infections in he...
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This guideline provides clinicians with evidence-based recommendations on the use of antifungal prophylaxis in children with cancer and undergoing hematopoietic stem cell transplantation (HSCT). Recommendations are divided into: (1) allogeneic HSCT (2) autologous HSCT (3) acute myeloid leukemia or myelodysplastic syndrome and (4) patients with malignancy and neutropenia for >7 days. A systemati...
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BACKGROUND Recurrence of prior invasive fungal infection (relapse rate of 30-50%) limits the success of stem cell transplantation. Secondary prophylaxis could reduce disease burden and improve survival. DESIGN AND METHODS A prospective, open-label, multicenter trial was conducted evaluating voriconazole (4 mg/kg/12 h intravenously or 200 mg/12 h orally) as secondary antifungal prophylaxis in ...
متن کاملImmunotherapy of invasive fungal infection in hematopoietic stem cell transplant recipients
Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Allogeneic HSCT recipients suffer from a long lasting defect of different arms of the immune system, which increases the risk for and deteriorates the prognosis of invas...
متن کاملPrimary antifungal prophylaxis in adult hematopoietic stem cell transplant recipients: current therapeutic concepts.
In recipients of hematopoietic stem cell transplants (HSCTs), the mortality associated with invasive fungal infections (IFIs) remains high, despite the introduction of broad-spectrum antifungal agents over the past 2 decades. Preventing exposure to fungal pathogens in this population is impossible; therefore, clinicians have focused on prophylactic use of antifungal agents to prevent IFIs in hi...
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تاریخ انتشار 2017